The missions of the CryoEM Core at Baylor College of Medicine include technology development driven by a diverse spectrum of biological samples to (1) achieve reliable atomic resolution structures of molecular machines; (2) derive structures from conformationally variable machines, and (3) characterize subcellular complexes within intact cells in normal and pathological states.
To accomplish this goal in the context of a national Research Resource, we pursue:
The equipment, techniques and expertise we develop are available to the research community through our collaborative projects. We currently have many active collaborative projects worldwide. Structural studies have been carried out with biological molecules which are the targets for preventing or curing various human diseases, including viral infections, cancer, atherosclerosis, coronary heart diseases, hypertension, tuberculosis, and neurological and genetic disorders.
The CryoEM Core also provides training through workshops and other forms of dissemination via both traditional and modern Internet-based methods. An animation specialist in NCMI is developing the tools to visualize complex three-dimensional structures generated from the image analysis and also the means to store and distribute the animations to the public. We have generated numerous animation productions for lecture presentations, teaching and research tools, journal and magazine publications and museum exhibits.
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